Clinical Biopsies

Clinical Biopsies

Our close links with clinical sites allows the ethical procurement of skin biopsy specimens from specific patient populations, such as those with Psoriasis or Atopic Dermatitis (AD), where the degree of disease, has been scored by a Physician.  Skin biopsies from both lesional and non-lesional (defined as an area with no previous flare history) sites can be obtained from the same patient.  Experimental set up and design allows both intra- and inter-patient comparison to be performed.

 

Biopsy specimens, when received at Biopta, are set up in an organoculture, as summarised on our Ex-vivo Cultures (organocultures) webpage.  Biopsy specimens can be cultured with a range of media containing stimulants such as interleukins or cytokines.  Alternatively the epidermal layer can be treated directly with the test compound of interest.  At the end of the culture period, analysis such as histology, immunocytochemistry or gene expression can be performed on the skin specimen.  The culture media supernatant can also be collected at defined points during the culture period for measurement of release of inflammatory markers and other substrates, providing a time course of treatment effects.

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