Psoriasis: Human tissue models for analysis of targets, pathways and therapeutic effects

Psoriasis: Human tissue models for analysis of targets, pathways and therapeutic effects

Psoriasis is a major focus of R&D in the pharmaceutical industry. Treatment options are limited and new therapies treating the underlying causes of psoriasis are needed. Biopta offers human fresh tissue models using both psoriatic biopsies and normal stimulated skin.

Two approaches to investigate potential treatments for psoriasis at Biopta

 
Induction of Th17 Phenotype in healthy human skin cultures
 

Higher throughput with up to 48 biopsies available from each patient. Multiple full thickness explants taken from healthy skin resection and cultured in the presence of a stimulatory cytokine cocktail

 
 

Click here to view our latest Th17 model client case study data

 

Psoriasis patient biopsy culture

Biopsies obtained from clinically diagnosed psoriasis patients with matched blood samples.

Compare plaque biopsies and biopsies from unaffected area in the same patient

Perform

  • Gene expression analysis
  • Immunohistochemistry
  • Assessment of mediator release
 
 
Click here for printable version of PDF flyer 

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