Respiratory

Respiratory

Biopta is able to offer an extensive range of assays in fresh human lung tissue from healthy and diseased non-transplantable lungs or surgical residual tissues.

Such living human tissues allow Biopta to investigate the effects of drugs on the human respiratory systems in a number of ways including:

  • Bronchodilatation/bronchoconstriction
  • Ion channel function (and hence epithelial secretion)
  • Inflammatory responses
  • Epithelial drug absorption

Effects on respiratory function are already required to be assessed as part of the ICH S7A core battery of tests prior to human exposure. Biopta’s respiratory assays allow the safety of your compound to be determined far in advance of the clinical development phase. Additionally, we are able to procure diseased tissues making it possible to carry out detailed safety studies on different patient populations making comparisons that would otherwise be impossible. Biopta’s assays provide the optimum model for research into a range of conditions such as COPD and asthma.

The graph below shows a comparison of effects of different beta-adrenoceptor agonists, reflecting the well known inter-individual variation in responses to salmeterol.

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