ADME - Respiratory

ADME - Respiratory

Lung or tracheal epithelial tissue can be assessed in the Ussing Chamber to determine changes in short circuit current (Isc) after exposure to your test compound.  This information is particularly valuable when assessing treatments for conditions like cystic fibrosis where fluid movement across airway epethelium is is disrupted resulting in thick mucus production.

Biopta has conducted a range of studies investigating specific ion channels in human or animal tracheal mucosa. Intact mucosa is dissected free from the trachea or primary bronchui and set up in Ussing chambers for measurement of functional responses. Figure 1 below shows the responses of human tracheal epithelium to the presence of increasing concentrations of the sodium channel blocker, amiloride.

 

 

Read our Industry Insight articles on Ussing chambers for more information or contact us to discuss protocols.

Visit our unique online catalogue of human functional tissue assays for standard protocols or contact Biopta at info@biopta.com to discuss a customised protocol with our team of expert scientists.

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