Drug Discovery Services: Lead Optimization

Drug Discovery Services: Lead Optimization

Accurately predict in vivo bioavailability and drug metabolism using human tissue, eliminating well known differences between human and alternative model systems.

Determine the Potency of Your Drug

  • Compare the potency of your candidate drug versus other drugs on the market.
Small intestine ileum Effect of Inhibitors of Chloride Secretion in Human Ileum

Increase the Confidence of Your First-in-Man Dose Estimate

  • Measure compound permeability, transporter, or metabolic enzyme activity in human intestinal tissue in order to accurately predict in vivo bioavailability and drug metabolism.
  • Eliminate well-known differences between human and animal or cell models in bioavailability and metabolism by using human tissue.
In vitro human gut permeability correlates well to expected clinical absorption

Find out more about our Lead Optimization and DMPK services »

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