Drug Discovery Services

Drug Discovery Services

Clinical trials for Investigational New Drugs (IND) are perhaps the biggest cost associated with drug development. And yet, up to 90% of all INDs fail at some phase in clinical trials. This is mainly attributable to the fact that most IND research and development is done in animal models and cell culture. The translation of efficacy, clinical safety and toxicology data to humans is not assured.


The ReproCELL Group has ready access to live human tissues through our extensive clinical networks, in addition to human iPSC-derived 3D cell model systems to create custom assays that can provide predictive human data to de-risk your drug discovery programs. No other company has this unique combination of expertise and capabilities.



Download the ReproCELL Europe Drug Discovery brochure (PDF)


We help our clients manage risk and save money


Demonstrating human efficacy and safety at an early stage of development has an enormous commercial value to our clients' research programs. For 10-20% of the drugs we have tested, the client decided to rethink their clinical strategy which seemed likely to fail based on the human tissue data. We estimate that this has resulted in net savings of more than $55 billion in total costs for our clients.






Determine the biological origin of the disease and potential targets for intervention using human tissue samples. Investigate receptor sites on particular cells that may be abberantly expressed in the disease state.


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Investigate the target's potential as a drug using fresh patient tissue or patient-specific iPSC-derived disease model cells.


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Perform high throughput screening of drug candidates on complex cell systems grown in 3D for physiologically meaningful data to identify potential leads.


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Accurately predict in vivo bioavailability and drug metabolism using human tissue, eliminating well known differences between human and alternative model systems.


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Are your test compounds safe in humans? Evaluate the pre-clinical safety of compounds using human tissue.


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Troubleshoot clinical problems by investigating the mechanisms of clinically-observed adverse effects using human fresh tissues.


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