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Species Differences

Species differences: better predicting drug activity. By Dr Emma Moss
In this article, Dr Emma Moss of Biopta considers whether species differences really matter during preclinical drug discovery. It is well known that the drug development process frequently uses in vitro and in vivo animal models to try and predict the safety and efficacy of drugs in humans, but is this a suitable approach and what can be done to address situations where species differences are identified? Download this article to learn more about comparative methods across species.
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Species Differences in the Control of Gastric Motility
Are species differences important to our understanding of preclinical to clinical translation. ? This article explores the responses to a common drug, erythromycin, and its effects on gastric motility. Do the marked species differences between humans, rats, rabbits and guinea pigs have any implications for models of gastric prokinetic effects?
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