Industry Insights

Experimental Methods

Ussing Chambers - A short hop from frog skin to human tissues. By David Arthur
Understanding gastrointestinal behaviour is often vitally important to the successful development of a new drug, from its oral delivery and absorption, to GI metabolism and the potential for drug-drug interactions. This article highlights Biopta's ability to assess new compounds in the most relevant and predictive model available - fresh human tissue.
Read More »

Huff and puff: Predicting the effects of new respiratory medicines need not be so difficult. By Lee Christie
As the industry turns towards phenotypic models of disease and seeks to better model immunological or functional aspects of human airways and pulmonary blood vessels, we ask which approaches can be taken and how they relate to diseases such as asthma, COPD and pulmonary hypertension.
Read More »

Blood vessel myography: a tale of two techniques. By Dr Emma Moss
Blood vessel myography is a valuable in vitro technique for the sensitive measurement of constriction and relaxation of blood vessels in response to test drugs. This article provides an overview of the different myography approaches available and why they are important for the pharmaceutical industry.
Read More »

Human vascular permeability measurements in vitro
Microvascular function is key in the regulation of blood pressure and vascular tone, however, disruption to microvascular function, is a factor in many diseases. Adverse drug effects may manifest through changes in microvascular function causing angioedema or vasodilatation. This article highlights the ability of Biopta's PM-1 system to provide accurate and sensitive measures of vascular function that can be used as a predictive in vitro model for vascular permeability.
Read More »

Live chat by BoldChat