Biopta is able to provide information on the permeability and absorption characteristics of your compounds in ex vivo human respiratory and gastrointestinal tissues by employing Ussing Chambers to mount intact sheets of human epithelium that retain all the relevant characteristics to model passive and active transport of substances.
The Ussing chamber allows measurement of short-circuit current through intact membranes, providing information on ion channel activity. Moreover, as the tissue is fresh and functional, transport across various regions of the GI tract or trachea/lung can be estimated and compared with data from animal systems or CaCo-2 models. for example, you might wish to compare the absorption of your compound in the stomach, small intestine and large intestine.
Biopta's test systems are the only available method to predict the actual absorption in intact fresh human tissues, the closest method to testing in the clinic.