Normally used to confirm the absence of off-target effects or prevent dilemmas caused by species variation, human vascular tissues are frequently available.
As part of our GLP vascular safety offering Biopta can screen for common observations as detailed in the table below.
|Small Resistance Arteries
||Vasoconstriction/Vasodilatation Changes in peripheral vascular resistance (indicates potential to alter blood pressure) Vascular Permeability (leakage)
|Large Conducting Arteries
Additionally, because of our ability to obtain tissue from donors of different ages and diseased states it is possible to be selective and assess responses in certain patient populations.
Studies are validated with a variety of reference compounds; example validation data below, however please contact us for further data and information.
Species differences in the response of human and dog resistance arteries to 5-hydroxytryptamine (serotonin).
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