Biopta is able to research many functions of human skin and subcutaneous tissues.
Fresh healthy tissue can be compared with diseased skin to provide comparisons of:
- Anti-inflammatory activity
- Free radical production
Subcutaneous vascular function Biopta’s organocultures of fresh human skin can be used to test topically-applied compounds such as anti-inflammatory creams or treatments for psoriasis.
Biopta is able to induce psoriasis and test the potency of treatments by examining keratinocyte proliferation. A rapid throughput of experiments can be achived, as great as that possible with artificial skin models, but with the advantages of using intact fresh human skin, which is a much more relevant model.
Responses to drugs applied to skin organocultures serve as a means to either quantify drug efficacy, for example of a topically applied anti-inflammatory, or to detect adverse effects, such as skin sensitivity.
Furthermore, drugs can be applied to the epidermis alone, which allows different drug formulations to be tested not only on the basis of their absorption characteristics but also the functional changes produced in the skin.